PUBLICATIONS

For a complete listing of publications , click here

2024

Jing Yang, Kathleen Ran, Wenzhe Ma, Yanshi Chen, Yanxi Chen, Can Zhang, Hui Ye, Ying Lu*, Chongzhao Ran* (2024) Degradation of Amyloid-β Species by Multi-Copper Oxidases. Journal of Alzheimer’s Disease. Aug 28. doi: 10.3233/JAD-240625

Rui Fang*, Luolan Bai, Boyan Li, Kevin Dong, Joao A Paulo, Mengying Zhou, Yi-Chi Chu, Yuyu Song, Michael Sherman, Christine Field, Timothy Mitchison*, Ying Lu* (2024) Episodic Transport of Protein Aggregates Achieves a Positive Size Selectivity in Aggresome Formation.  BioRxiv 606767. [Preprint].  Aug. 07, 2024.  Available from: https://doi.org/10.1101/2024.08.06.606767  *Co-corresponding author

2023

Lee D, Zhu Y, Colson L, Wang X, Chen S, Tkacik E, Huang L, Ouyang Q, Goldberg AL, Lu Y. Molecular mechanism for activation of the 26S proteasome by ZFAND5. Mol Cell. 2023 Aug 17;83(16):2959-2975.e7. doi: 10.1016/j.molcel.2023.07.023. PubMed PMID: 37595557; PubMed Central PMCID: PMC10523585.

Zhou M, Fang R, Colson L, Donovan KA, Hunkeler M, Song Y, Zhang C, Chen S, Lee DH, Bradshaw GA, Eisert R, Ye Y, Kalocsay M, Goldberg A, Fischer ES, Lu Y. HUWE1 Amplifies Ubiquitin Modifications to Broadly Stimulate Clearance of Proteins and Aggregates. bioRxiv. 2023 May 30;. doi: 10.1101/2023.05.30.542866. PubMed PMID: 37398461; PubMed Central PMCID: PMC10312588.

Lee D, Zhu Y, Colson L, Wang X, Chen S, Tkacik E, Huang L, Ouyang Q, Goldberg AL, Lu Y. Molecular mechanisms for activation of the 26S proteasome. bioRxiv. 2023 May 10;. doi: 10.1101/2023.05.09.540094. PubMed PMID: 37214989; PubMed Central PMCID: PMC10197607.

2022

Jiménez A, Lu Y, Jambhekar A, Lahav G. Principles, mechanisms and functions of entrainment in biological oscillators. Interface Focus. 2022 Jun 6;12(3):20210088. doi: 10.1098/rsfs.2021.0088. eCollection 2022 Jun 6. Review. PubMed PMID: 35450280; PubMed Central PMCID: PMC9010850.

Hung KYS, Klumpe S, Eisele MR, Elsasser S, Tian G, Sun S, Moroco JA, Cheng TC, Joshi T, Seibel T, Van Dalen D, Feng XH, Lu Y, Ovaa H, Engen JR, Lee BH, Rudack T, Sakata E, Finley D. Allosteric control of Ubp6 and the proteasome via a bidirectional switch. Nat Commun. 2022 Feb 11;13(1):838. doi: 10.1038/s41467-022-28186-y. PubMed PMID: 35149681; PubMed Central PMCID: PMC8837689.

Fang R, Hon J, Zhou M, Lu Y. An empirical energy landscape reveals mechanism of proteasome in polypeptide translocation. Elife. 2022 Jan 20;11. doi: 10.7554/eLife.71911. PubMed PMID: 35050852; PubMed Central PMCID: PMC8853663.

2020

Ka Ying Sharon Hung, Sven Klumpe, Markus R. Eisele, Suzanne Elsasser, Geng Tian, Shuangwu Sun, Jamie A. Moroco, Tat Cheung Cheng, Tapan Joshi, Timo Seibel, Duco Van Dalen, Xin-Hua Feng, Ying Lu, Huib Ovaa, John R. Engen, Byung-Hoon Lee, Till Rudack, Eri Sakata and Daniel Finley (2022).  Allosteric control of Ubp6 and the proteasome via a bidirectional switch. Nature Communication  Feb 11. doi: 10.1038/s41467-022-28186-y    

https://www-nature-com.ezp-prod1.hul.harvard.edu/articles/s41467-022-28186-y

Alba Jiménez, Ying Lu, Ashwini Jambhekar, Galit Lahav (2022).  Principles, mechanisms and functions of entrainment in biological oscillators. Interface Focus. 12(3): 20210088  *review article https://royalsocietypublishing-org.ezp-prod1.hul.harvard.edu/doi/full/10.1098/r…

Rui Fang, Jason Hon, Mengying Zhou and Ying Lu* (2022). An empirical energy landscape reveals the mechanism of proteasome in polypeptide translocation. eLife. 10.7554/eLife.71911 https://elifesciences.org/articles/71911v1

2019

Yuanchen Dong, Shuwen Zhang, Zhaolong Wu. Xuemei Li, Wei Li Wang, Yanan Zhu, Svetla Stoilova-McPhie, Ying Lu, Daniel Finley, Youdong Mao.   Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome. Nature 2019 Jan;565(7737):49-55 http://www.pubmed.com/30479383

Jason Hon, Ying Lu.  Single-molecule methods for measuring ubiquitination and protein stability.  Methods Enzymol. 2019;619:225 247.  http://www.pubmed.com/30910022

2018

Yanan Zhu, Wei Li Wang, Daqi Yu, Qi Ouyang, Ying Lu*, Youdong Mao* (2017). Structural mechanism for nucleotide-driven remodeling of the AAA-ATPase unfoldase in the activated human 26S proteasome.   Nat Commun. 2018 Apr 10;9(1):1360.  * Co-corresponding author http://www.pubmed.com/29636472

2017

Ying Lu*, Jiayi Wu*, Yuanchen Dong, Shuobing Chen, Shuangwu Sun, Yong-Bei Ma, Qi Ouyang, Daniel Finley, Marc W. Kirschner, Youdong Mao (2017). Conformational Landscape of the p28-bound Human Proteasome Regulatory Particle. Molecular Cell Jul 20;67(2):322-333 *equal contribution https://pubmed.ncbi.nlm.nih.gov/28689658/

2016

Shuobing Chen*, Jiayi Wu*, Ying Lu*, Yong-Bei Ma, Byung-hoon Lee, Zhou Yu, Qi Ouyang, Daniel J. Finley, Marc W. Kirschner, and Youdong Mao (* equal contribution). 10/21/2016. “Structural Basis for Dynamic Regulation of The Human 26S Proteasome.” PNAS , 46, 113: 12991-12996.

Nicholas G. Brown, Ryan VanderLinden, Edmond R. Watson, Florian Weissmann, Alban Ordureau, Kuen-Phon Wu, Wei Zhang, Shanshan Yu, Joseph S. Harrison, Renping Q. Coudevylle, Iain F. Davidson, Ying Lu, Prakash Dube, Michael R. Brunner, Christy R. R. Grace, Darcie J. Miller, Marc A. Jarvis, Masaya Yamaguchi, Peter Y. Mercredi, Sachdev S. Sidhu, Brian Kuhlman, Marc W. Kirschner, J. Wade Harper, Jan-Michael Peters, Holger Stark, and Brenda A. Schulman. 6/2/2016. “Dual RING E3 Architectures for Substrate Polyubiquitination Visualized for Anaphase Promoting Complex/Cyclosome.” Cell, 6, 165: 1440–1453. Publisher's Version

Byung-hoon Lee, Ying Lu, Miguel A. Prado, Yuan Shi, Shuangwu Sun, Suzanne Elsasser, Marc W. Kirschner, Steven P. Gygi, Randall W. King, and Daniel Finley. 4/21/2016. “USP14 Deubiquitinates Proteasome-bound Substrates that are Ubiquitinated at Multiple Sites.” Nature, 532: 398–401. Publisher's Version

2015

Ying Lu, Weiping Wang, and Marc W. Kirschner. 4/10/2015. “Specificity of the Anaphase-Promoting Complex: A Single-Molecule Study.” Science, 6231, 348. Publisher's Version

Ying Lu, Byung-hoon Lee, Randall King, Daniel Finley, and Marc W. Kirschner. 4/10/2015. “Substrate Degradation by the Proteasome: A Single-Molecule Kinetic Analysis.” Science, 6231, 348: 1250834. Publisher's Version

2013

Hidefumi* Fukushima, Lixin* Wan, Hiroyuki* Inuzuka, Ying Lu*, Daming Gao, Victor Li, Pengda Liu, Alan W Lau, Tao Wu, Marc W. Kirschner, and Wenyi (* equal contribution) Wei. 8/29/2013. “SCF-mediated Cdh1 Destruction Defines a Negative Feedback Regulation to Coordinate Cell Cycle Progression.” Cell Reports, 4, 4: 803–816. Publisher's Version

2010

Ying Lu and Frederick Cross. 4/16/2010. “Periodic Cyclin-Cdk Activity Entrains an Autonomous Cdc14 Release Oscillator.” Cell, 2, 141: 224-226. Publisher's Version

2009

Benjamin J. Drapkin, Ying Lu, Andrea L. Procko, Benjamin L. Timney, and Frederick R. Cross. 11/17/2009. “1. Analysis of The Mitotic Exit Control System Using Locked Levels of Stable Mitotic Cyclin.” Molecular System Biology, 5: 328. Publisher's Version

Ying Lu and Frederick Cross. 3/1/2009. “Mitotic Exit in the Absence of Separase Activity.” Mol Biol Cell, 5, 20: 1576-91. Publisher's Version

2004

Xiaonan Wang, Ying Lu, Minxi Jiang, and Xi Ouyang. 5/27/2004. "Attraction of spiral waves by localized inhomogeneities with small-world connections in excitable media." Physical Review E, 5, 69: 056223. Publisher's Version

Fangting Li*, Tao Long*, Ying Lu*, Chao Tang, and Qi Ouyang (*equal contribution). 4/6/2004. “The Yeast Cell-Cycle Network is Robustly Designed.” PNAS, 14, 101: 4781-6. Publisher's Version

OLDER

For older publications, please search for Lu, Ying on PubMed.