200 Longwood Avenue
Warren Alpert Building, 5th Floor
Boston, MA 02115
Hello, my name is Yi-Chi Chu. I joined the Lu lab in 2022 as a research technician. I graduated from UCSC with a degree in molecular biology and chemistry.
My name is Louis Colson. I am currently a 4th year student in the school of engineering. My work is to implement single-molecule fluorescence microscopy to investigate how the proteasome machine works in selecting and degrading protein targets. Happy to discuss my project.
Hi~~ , I am currently a 5th year graduate student in the MCO program. I have joined the Lu Lab since 2019. My research project is to investigate how the ubiquitin-proteasome system helps to dismantle the disease-causing protein aggregates in the cell. I have a published study of simulating the conformational dynamics of the proteasome ATPase complex using its empirical free-energy landscape. Happy to discuss about my work!
My doctoral studies were accomplished at Tsinghua University, Beijing in 2016. During my Ph.D., I studied the assembly of mammalian Apaf-1 apoptosome and the activation of cell-killing caspases involved in the onset of intrinsic apoptosis using single-particle cryo-electron microscopy (cryo-EM), as well as biochemical and genetic methods. I joined the Lu lab as a postdoctoral fellow in 2017. I’m interested in combining single-molecule kinetics, structural studies and biochemical analyses to obtain a complete description possible of the protein complexes.