People
Jason Hon
Jason earned his PhD in Chemistry from Columbia University in 2017 under Dr. Ruben Gonzalez, studying RNA dynamics using single-molecule techniques. His research focused on developing assays and computational algorithms to study microsecond-scale intermediates between RNA helix-coil transitions using single-molecule field effect transistors (smFETs). As an undergraduate, Jason Hon studied reversible inhibition of protein tyrosine phosphatase 1B (PTP1B) by Vanadium (IV) chelates under Dr. Marvin Makinen at the University of Chicago.
Mengying Zhou
My doctoral studies were accomplished at Tsinghua University, Beijing in 2016. During my Ph.D., I studied the assembly of mammalian Apaf-1 apoptosome and the activation of cell-killing caspases involved in the onset of intrinsic apoptosis using single-particle cryo-electron microscopy (cryo-EM), as well as biochemical and genetic methods. I joined the Lu lab as a postdoctoral fellow in 2017. I’m interested in combining single-molecule kinetics, structural studies and biochemical analyses to obtain a complete description possible of the protein complexes.